Viral inactivation during purification of antibodies

Details Viral inactivation during purification of antibodies Viral inactivation during purification of antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2738499

Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography.

L'invention concerne des procédés d'isolation et de purification d'anticorps d'une matrice d'échantillonnage. Un aspect de la présente invention concerne la réduction/inactivation virale d'échantillons générés dans les diverses des étapes de purification d'anticorps. Dans un aspect particulier, des procédés de l'invention utilisent une étape d'acidification suivie d'une de plusieurs étapes de chromatographie. Les étapes de chromatographie peuvent comprendre une ou plusieurs des méthodes chromatographiques suivantes : la chromatographie à échange d'ions, la chromatographie d'affinité et la chromatographie d'interactions hydrophobes.

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