Viral inhibitory nucleotide sequences and vaccines

Details Viral inhibitory nucleotide sequences and vaccines Viral inhibitory nucleotide sequences and vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 39/21 (2006.01) C07H 21/00 (2006.01) C12N 7/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/33 (2006.01) C12N 15/67 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2657626

The invention relates to inhibitory nucleotide signal sequences or "INS" sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.

L'invention porte sur des séquences signal nucléotidiques inhibitrices ou séquences <= INS >= dans les génomes des lentivirus. En particulier, l'invention porte sur le motif AGG présent dans tous les génomes viraux. Le motif AGG peut avoir un effet inhibiteur sur un virus, par exemple, par la réduction des taux, ou le maintien de taux faibles à l'état stable, d'ARN viraux dans des cellules hôtes, et l'induction et/ou le maintien dans une latence virale. Sous un aspect, l'invention concerne des vaccins contenant ou produits à partir d'acides nucléiques viraux dans lesquels les séquences AGG ont été mutées. Sous un autre aspect, l'invention concerne des procédés et des compositions pour affecter la fonction du motif AGG, et des procédés pour identifier d'autres séquences INS dans les génomes viraux.

Affiliated with

Also associated with

Rating

Viral inhibitory nucleotide sequences and vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Viral inhibitory nucleotide sequences and vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Viral inhibitory nucleotide sequences and vaccines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2045153