Viral particle-like construct and method of forming the same...

Details Viral particle-like construct and method of forming the same... Viral particle-like construct and method of forming the same...

C - Chemistry, Metallurgy

07

K

C07K 14/025 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 43/00 (2006.01) C07K 19/00 (2006.01) C12N 15/37 (2006.01)

Patent

CA 2572129

It is intended to provide a novel method of forming uniform viral particles under physiological conditions. Namely, a method of forming a mass of viral particles in a uniform size made of a viral protein, characterized by comprising incubating a viral protein (for example, VP1 of SV40 virus) at pH 5.0 to pH 7.0 and at room temperature in the presence of 130 mM to 170 mM of sodium chloride and 1.5 mM to 2.5 mM of a divalent cation and in the presence of a particle-formation promoter such as VP2 of SV40. In the case where it is needed to enclose a substance in the viral particles, the substance to be enclosed may be allowed to coexist in the incubation as described above.

Nouveau procédé de formation de particules virales uniformes dans des conditions physiologiques et procédé de formation d'une masse de particules virales ayant une taille uniforme faites d'une protéine virale, caractérisé en ce qu'il comprend d'incuber une protéine virale (par exemple la VP1 du virus SV40) à pH 5,0 à 7,0 et à température ambiante en présence de 130 mM à 170 mM de chlorure de sodium et de 1,5 mM à 2,5 mM d'un cation divalent et en présence d'un promoteur de formation de particules tel que la VP2 du SV40. Dans le cas où on a besoin d'inclure une substance dans les particules virales, on peut permettre à la substance à inclure d'être présente en même temps dans l'incubation telle que décrite ci-dessus.

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