Viral polymerase inhibitors

Details Viral polymerase inhibitors Viral polymerase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/41 (2006.01) A61K 31/4184 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/498 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61P 31/14 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2553879

An enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein either A or B is nitrogen and the other B or A is C, and the radicals R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof as viral polymerase inhibitors. The compound is used as an inhibitor of RNA dependent RNA polymerases, particularly those viral polymerases within the Flaviviridae family, more particularly to HCV polymerase.

La présente invention a trait à un enantiomère, diastéréoisomère ou tautomère d'un composé de formule (I), dans laquelle : A ou B est azote et l'autre B ou A est C ; et les radicaux R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, et R?10¿ sont tels que définis dans la description, ou un sel ou ester de celui-ci en tant qu'inhibiteurs de la polymérase virale. Le composé est utilisé comme inhibiteur de polymérases d'ARN dépendant de l'ARN, notamment ces polymérases virales au sein de la famille des Flaviviridae, plus particulièrement la polymérase du virus de l'hépatite C.

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