C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/048 (2006.01) A61K 31/4188 (2006.01) A61P 31/12 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2618682
The present invention relates to compounds represented by formula (I) wherein A, B, D, E, R2, R3, R4, R5, R6, R9, a, b, d and e are as defined herein, their salt or ester and pharmaceutical compositions thereof useful in the treatment of hepatitis C viral (HCV) infection. Said compounds were found to have inhibitory activity against HCV polymerase, especially as inhibitors of HCV NS5B polymerase
La présente invention concerne des composés de formule (I) où A, B, D, E, R2, R3, R4, R5, R6, R9, a, b, d et e sont tels que définis dans la description, leur sel ou ester, ainsi que des préparations pharmaceutiques incluant ces composés et pouvant être employées dans le traitement d'une infection par le virus de l'hépatite C (VHC). Il a été découvert que lesdits composés présentaient une activité inhibitrice vis-à-vis de la polymérase du VHC, en particulier vis-à-vis de la polymérase NS5B du VHC.
Boehringer Ingelheim International Gmbh
Looper Ywe J.
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