Viral recombinant pseudo-particles and vaccinal and...

Details Viral recombinant pseudo-particles and vaccinal and... Viral recombinant pseudo-particles and vaccinal and...

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/12 (2006.01) A61K 39/23 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) C07K 14/015 (2006.01) C07K 14/02 (2006.01) C07K 14/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2241280

Viral recombinant pseudo-particles characterized in that they are formed by self-assembly of at least one protein having a viral structure, in that they have a size comprised between about 20 and 60 nm, in that they form an approximately icosahedral structure, an in that said protein is modified by the presence of at least one epitope comprising a sequence from 8 to 25 amino acids which is susceptible of association to at least one molecule of class I and/or II of the major histocompatibility complex, with the exclusion of the epitope C3:T, said association being recognized by cytotoxic lymphocytes TCD8?+¿ and/or TCD4?+¿. Said pseudo-particles may be used as anti-viral vaccines or as medicaments.

Pseudo-particules virales recombinantes caractérisées en ce qu'elles sont constituées par auto-assemblage d'au moins une protéine de structure virale, en ce qu'elles ont une taille comprise entre environ 20 et 60 nm, en ce qu'elles forment une structure approximativement icosaédrique, et en ce que ladite protéine est modifiée par la présence d'au moins un épitope comprenant une séquence de 8 à 25 acides aminés susceptibles de s'associer à au moins une molécule de classe I et/ou II du complexe majeur d'histocompatibilité, à l'exclusion de l'épitope C3:T, ladite association étant reconnue par des lymphocytes TCD8+ cytotoxiques et/ou TCD4+. Ces pseudo-particules peuvent être utilisées comme vaccins antiviraux ou comme médicaments.

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