Viral replicons and viruses dependent on inducing agents

Details Viral replicons and viruses dependent on inducing agents Viral replicons and viruses dependent on inducing agents

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) C12N 7/04 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12N 15/867 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2386530

In one aspect the invention provides an inducible viral replicon, comprising at least one inducible repressor and/or activator, and all viral sequences which are essential for replication under direct or indirect control of said inducible repressor and/or activator. Said inducible repressor and/or activator may comprise a Tet operon. A replicon of the invention may be used to produce a virus, for instance an attenuated HIV virus, which can be induced to replicate by the presence of doxycycline or a functional analog thereof. Said replicon and/or said produced virus is suitable for the preparation of a vaccine, for instance for the prophylaxis of AIDS. A replicon of the invention can be modified, preferably improved, by a method termed force evolution.

Selon un aspect, l'invention concerne un réplicon viral inductible comprenant au moins un répresseur inductible et/ou un activateur, et toutes les séquences virales qui sont essentielles à la réplication sous contrôle directe ou indirecte dudit répresseur inductible et/ou activateur. Ce répresseur inductible et/ou activateur peut comprendre un opéron Tet. On peut utiliser un réplicon de cette invention pour produire un virus, par exemple un virus atténué du VIH, qui peut être induit pour se répliquer en présence de doxycycline ou d'un analogue fonctionnel correspondant. Ledit réplicon et/ou ledit virus produit est approprié à la préparation d'un vaccin, destiné par exemple à la prophylaxie du SIDA. On peut modifier un réplicon de cette invention, l'améliorer de préférence, par le biais d'une évolution forcée décrite par la méthode.

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