Viral treatment

Details Viral treatment Viral treatment

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 38/55 (2006.01) A61P 31/10 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2365495

A pharmaceutical composition that inhibits or slows the growth of viruses is disclosed. This same composition can be used to treat viral infections, particularly HIV and hepatitis as well as fungal infections of the genus cryptococcus neoformans or curvularai lunata. The composition comprises from about 10 mg to about 6000 mg of a 2-thienyl-imidazolo[4,5]pyridine of formula (I), wherein n is from 1 to 4, R is selected from the group consisting of hydrogen, alkyl having from 1 to 7 carbon atoms, chloro, bromo or fluoro, oxychloro, hydroxy, sulfhydryl, alkoxy having the formula: -O(CH2)y CH3, wherein y is from 1 to 6, the prodrugs thereof, and the pharmaceutically acceptable salts thereof. The preferred anti-viral compound is (a) and its hydrochloride salt. Mixtures of the 2-thienyl-imidazolo[4,5]pyridines with other antiviral agents or potentiators (AZT, 3-TC(lamivudine) or protease inhibitors for example) can also be used to treat viral infections.

L'invention concerne une composition pharmaceutique inhibant ou ralentissant la croissance de virus. On peut utiliser cette composition pour traiter des infections à virus, notamment le VIH et l'hépatite, ainsi que des infections fongiques du genre cryptococcus neoformans ou curvularai lunata. Ces compositions comprennent environ 10 à environ 6000 mg of d'une 2-thiényl-imidazolo[4,5]pyridine correspondant à la formule (I), dans laquelle n vaut 1 à 4, R est choisi dans le groupe constitué par hydrogène, alkyle possédant 1 à 7 atomes de carbone, chloro, bromo ou fluoro, oxychloro, hydroxy, sulfhydryle, alcoxy possédant la formule: -O(CH2)yCH3, où y vaut 1 à 6. L'invention concerne également des promédicaments et sels de ce composé, acceptables sur le plan pharmacologique. Le composé antiviral (et son chlorhydrate) que l'on préfère correspond à la formule (a). On peut également utiliser des mélanges de 2-thiényl-imidazolo[4,5]pyridines pour traiter des infections à virus.

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