Viral treatment

Details Viral treatment Viral treatment

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/00 (2006.01) A61K 31/513 (2006.01) A61K 31/7072 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01) A61P 31/16 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006.01) A61P 43/00 (2006.01) C07D 223/10 (2006.01)

Patent

CA 2368647

A pharmaceutical composition that inhibits or slows the growth of viruses in animals, particularly in mammals, is disclosed. This same composition can be used to treat viral infections, particularly HIV. The composition comprises from about 10 mg to about 10000 mg of a carbamic acid ester derivative of formula (I) wherein X is independently oxygen or sulfur, R is selected from the group consisting of hydrogen and alkyl having from 1 to 4 carbon atoms, R1 is selected from the group consisting of hydrogen and alkyl having from 1 to 4 carbon atoms, wherein R2 is independently selected from the group consisting of hydrogen and alkyl having from 1 to 4 carbon atoms, and wherein Y is selected from the group consisting of hydrogen, chloro, fluoro, bromo, hydroxy, oxychloro and sulfhydryl or pharmaceutical addition salt or prodrug thereof. The most preferred compound is (4-chlorophenyl)-carbamic acid, 3- (hexahydro-3-ethyl-1-methyl-2-oxo-1H-azepin-3-yl) 2 phenyl ester.

L'invention concerne une composition pharmaceutique inhibant ou ralentissant la croissance des virus chez des animaux, notamment chez des mammifères. On peut utiliser cette composition pour traiter des infections à virus, notamment le VIH. Cette composition contient environ 10 à environ 10 000 mg d'ester d'acide carbamique correspondant à la formule (I) dans laquelle X représente indépendamment oxygène ou soufre, R est choisi dans le groupe constitué par hydrogène et alkyle possédant 1 à 4 atomes de carbone, R¿1? est choisi dans le groupe constitué par hydrogène et alkyle possédant 1 à 4 atomes de carbone, R¿2? représente indépendamment hydrogène ou alkyle possédant 1 à 4 atomes de carbone, Y est choisi dans le groupe constitué par hydrogène, chloro, fluoro, bromo, hydroxy, oxychloro et sulfhydryle. L'invention concerne également un sel d'addition ou promédicament de ce composé. Le composé que l'on préfère est un ester de 3-(hexahydro-3-éthyl-1-méthyl-2-oxo-1H-azépin-3-yl)2 phényle de l'acide (4-chlorophényl)carbamique.

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