Viral vaccine conjugates

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/42 (2006.01) A61K 39/12 (2006.01) C07K 16/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2066661

A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine conjugate consisting essentially of a live virus and a neutralizing factor bound to the live virus. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live virus is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live virus. Preferred subjects are birds, a preferred virus is Infectious Bursal Disease Virus, and a preferred route of administration to birds is by in ovo administration.

Un procédé induisant une immunité active contre une maladie virale chez un sujet animal, consiste à administrer au sujet un conjugué de vaccin composé essentiellement d'un virus vivant et d'un facteur neutralisant lié au virus vivant. Le facteur neutralisant est choisi dans le groupe composé d'anticorps et de fragments d'anticorps. Le virus vivant est du type capable d'induire une maladie chez un sujet, et l'anticorps ou le fragment d'anticorps est du type capable de neutraliser le virus vivant. Les sujets préférés sont les oiseaux, un virus préféré est le virus de la maladie de la bourse infectieuse, et une voie d'administration préférée à des oiseaux est la voie in ovo.

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