Viral variants and methods for detecting same

Details Viral variants and methods for detecting same Viral variants and methods for detecting same

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) C07K 14/02 (2006.01) C12N 7/00 (2006.01) C12N 9/12 (2006.01) C12N 15/36 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2270178

The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B variants exhibiting complete or partial resistance to nucleoside analogues and/or reduced interactivity with antibodies to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes.

L'invention concerne en général des variantes virales présentant soit une sensibilité limitée à des agents particuliers, soit une interactivité limitée avec des réactifs immunologiques. Elle concerne, plus particulièrement, des variantes de l'hépatite B présentant soit une résistance complète ou partielle à des analogues de nucléosides, soit une interactivité limitée avec des anticorps contre des éléments viraux superficiels. Elle concerne, de plus, des procédés servant à détecter ces variantes virales, ces procédés étant utiles au contrôle de traitements thérapeutiques antiviraux.

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