C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 39/29 (2006.01) C07K 14/02 (2006.01) C12N 9/12 (2006.01) C12N 15/51 (2006.01) C12N 15/54 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2409983
The present invention relates generally to viral variants exhibiting reduced sensitivity to agents and in particular nucleoside analogues. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues. The variants may also comprise corresponding mutations affecting immunological interactivity to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
La présente invention concerne de façon générale des variantes virales présentant une sensibilité réduite à certains agents, et particulièrement des analogues nucléosidiques. Plus précisément, cette invention concerne des variantes virales de l'hépatite B présentent une résistance partielle ou totale aux analogues nucléosidiques. Ces variantes peuvent également comprendre des mutations correspondantes qui affectent l'interactivité immunologique face aux composants viraux de surface. Par ailleurs, cette invention concerne des dosages permettant de détecter des variantes virales de ce type, lesquels dosages permettent de contrôler les schémas thérapeutiques antiviraux et de mettre au point de nouveaux vaccins ou de modifier des vaccins contre les agents viraux, et en particulier, contre les variantes du virus de l'hépatite B. De plus, cette invention concerne l'utilisation de ces variantes virales dans le criblage d'agents capables d'inhiber l'infection, la réplication et/ou la libération du virus.
Angus Peter William
Ayres Anna
Bartholomeusz Angeline Ingrid
Littlejohn Margaret Rose
Locarnini Stephen Alister
Central Sydney Area Health Service
Melbourne Health
Smart & Biggar
The Austin And Repatriation Medical Centre
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