C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/85 (2006.01) C12N 15/869 (2006.01)
Patent
CA 2238981
Constructs for delivery of sequences of interest to cells include a herpes virus latency active promoter (LAP) of the latency associated transcript (LAT) region. An internal ribosome entry site (IRES) is located downstream of the LAP, with a nucleotide sequence of interest downstream of the IRES. Stable, long-term expression, including export of mRNA to the cytoplasm and translation of the encoded polypeptide, is found in neuronal and non-neuronal cells.
Des constructions permettant d'introduire des séquences à étudier dans des cellules comprennent un promoteur actif pendant la latence (LAP) de la région du transcript associé à la latence (LAT) de l'herpèsvirus. Un site d'entrée ribosomique interne (IRES) est localisé en aval du LAP, avec une séquence nucléotidique à étudier en aval de l'IRES. On trouve une expression stable, durable, comprenant l'exportation de l'ARNm vers le cytoplasme et la translation du polypeptide codé, dans les neurones et dans d'autres cellules.
Efstathiou Stacey
Lachmann Robin Henry
Bereskin & Parr
Cambridge University Technical Services Limited
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