C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 15/63 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01) C12N 15/869 (2006.01)
Patent
CA 2568898
The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or absence of a small molecule regulator. The gene switch controls the expression of a gene for a protein required for efficient viral replication and may also control the activity of a passenger gene.
L'invention concerne la réplication conditionnelle de virus ou de paires de virus contenant une commutation génique activable par une contrainte thermique ou une autre contrainte protéotoxique transitoires en présence ou en l'absence d'un régulateur de petites molécules. Cette commutation génique régule l'expression d'un gène pour une protéine nécessaire à une réplication virale efficace et peut également réguler l'activité d'un gène passager.
Hsf Pharmaceuticals S.a.
Smart & Biggar
LandOfFree
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