Viral vectors having reduced virulence

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 38/00 (2006.01) C12N 7/04 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12N 15/863 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2444743

The present invention provides recombinant vaccinia virus having a deletion of the region encoding the C-terminal seven amino acids of the E3L gene product and commprising exogenous DNA. Compositions comprising the recombinant vaccinia virus and methods of use thereof are also provided.

La présente invention concerne un virus de vaccine de recombinaison qui présente une délétion de la région codant les 7 aminoacides de la région C-terminale du produit génique E3L et comprenant de l'ADN exogène. Des compositions comprenant le virus de vaccine de recombinaison et des méthodes d'utilisation de ces dernières sont également présentées.

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