C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/04 (2006.01) A61K 9/127 (2006.01) A61K 39/145 (2006.01) A61K 39/29 (2006.01)
Patent
CA 2585309
The present invention provides a virosome comprising a virosomal membrane comprising at least one lipid and envelope proteins of an enveloped virus and of the virosome and attached to said envelope proteins. Furthermore, the invention provides a vaccine comprising the virosome of the invention and, a method for theproduction of a virosome of the invention. Moreover, the invention provides a use of a virosome of the invention for the preparation of a vaccine, e.g. for the prevention or alleviation of a disease related to an HBV infection, and a method for the vaccination of a subject.
L'invention concerne un virosome qui comprend une membrane virosome renfermant au moins un lipide et des protéines enveloppes de virus enveloppé ainsi que des particules nucléocapsides du virus en question à l'intérieur et à l'extérieur du virosome et fixées à ces protéines. L'invention concerne aussi un vaccin qui renferme le virosome considéré et un procédé de production de ce virosome. On décrit enfin l'utilisation d'un tel virosome pour l'élaboration d'un vaccin, par exemple pour la prévention ou le traitement d'une maladie liée à une infection par le virus de l'hépatite B (HBV), et un procédé de vaccination de patient.
Assero Giovanna
Felnerova Diana
Fichera Epifanio
Lempereur Laurence
Moser Christian
Berna Biotech Ag
Borden Ladner Gervais Llp
Crucell Switzerland Ag
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