C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/112 (2006.01) A61K 45/06 (2006.01) C07K 14/255 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 9/52 (2006.01) C12N 15/11 (2006.01) C12N 15/31 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2623339
A method for identifying a microorganism having a reduced adaptation to a particular environment comprising the steps of: (1) providing a plurality of microorganisms each of which is independently mutated by the insertional inactivation of a gene with a nucleic acid comprising a unique marker sequence so that each mutant contains a different marker sequence, or clones of the said microorganism; (2) providing individually a stored sample of each mutant produced by step (1) and providing individually stored nucleic acid comprising the unique marker sequence from each individual mutant; (3) introducing a plurality of mutants produced by step (1) into the said particular environment and allowing those microorganisms which are able to do so to grow in the said environment; (4) retrieving microorganisms from the said environment or a selected part thereof and isolating the nucleic acid from the retrieved microorganisms; (5) comparing any marker sequences in the nucleic acid isolated in step (4) to the unique marker sequence of each individual mutant stored as in step (2); and (6) selecting an individual mutant which does not contain any of the marker sequences as isolated in step (4).
Hensel Michael
Holden David William
Shea Jacqueline Elizabeth
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Emergent Product Development Uk Limited
Imperial College Innovations Limited
Microscience Limited
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