Virus envelope vector for gene transfer

Details Virus envelope vector for gene transfer Virus envelope vector for gene transfer

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01)

Patent

CA 2369491

A gene transfer vector is prepared by introducing an exogenous gene into an inactivated virus envelope, through a freezing and thawing treatment or mixing with a detergent. There are also provided a pharmaceutical composition for gene therapy containing this gene transfer vector, a kit containing this gene transfer vector, and a gene transfer method employing this gene transfer vector.

Selon l'invention, un gène étranger est transféré dans une enveloppe virale inactivée par le procédé de congélation et décongélation, ou par mélange avec un agent tensioactif, dans le but de préparer un vecteur de transfert de gène. Cette invention concerne aussi des compositions médicinales de thérapie génique contenant ce vecteur de transfert de gène, des nécessaires contenant ce vecteur, ainsi qu'un procédé de transfert de gène utilisant ce vecteur.

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