Virus immunologic determinants

Details Virus immunologic determinants Virus immunologic determinants

C - Chemistry, Metallurgy

12

N

C12N 15/34 (2006.01) A61K 39/21 (2006.01) A61K 39/235 (2006.01) C07K 14/075 (2006.01) C07K 14/15 (2006.01) C12N 7/00 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2372242

Polypeptides of virus that bind to virus antibodies or block binding of virus to mammalian cells are described. Derivatives of peptides can be less immunogenic, enhance binding to cells, render a virus tissue specific and so on. The nucleic acid sequence encoding those derivatives can be incorporated into a capsid encoding sequence to enable a virus to express such a derivative and be less immunogenic, have enhanced transduction efficiency or be tissue specific.

L'invention concerne des polypeptides de virus se liant aux anticorps d'un virus ou la liaison en bloc d'un virus à des cellules mammaliennes. Des dérivés de peptides peuvent être moins immunogènes, améliorer la liaison aux cellules, rendre un virus spécifique d'un tissu, ainsi de suite. La séquence d'acides nucléiques codant pour ces dérivés peut être introduite dans une séquence de codage d'une capside pour permettre à un virus d'exprimer ce dérivé et d'être moins immunogène, de présenter une plus grande efficacité de transduction ou d'être spécifique d'un tissu.

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