C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/08 (2006.01) A61K 39/12 (2006.01) C07K 14/005 (2006.01) C12N 7/01 (2006.01) C12N 15/40 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2733589
The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
La présente invention concerne des polypeptides qui présentent une séquence d'acides aminés composite provenant d'une séquence de consensus représentant les protéines de capside dau moins deux souches en circulation d'un virus non enveloppé. En particulier, l'invention fournit des particules similaires à un virus comportant au moins un polypeptide composite. De telles particules similaires à un virus ont des épitopes antigéniques dau moins deux souches en circulation d'un virus non enveloppé, et produisent une augmentation de réactivité croisée d'antisérum pour une ou plusieurs souches en circulation du virus non enveloppé. Des procédés de fabrication de particules similaires à un virus composites et de formulations de vaccin comportant des particules similaires à un virus composites sont également décrits.
Bargatze Robert
Haynes Joel
Richardson Charles
Steadman Bryan
Deeth Williams Wall Llp
Ligocyte Pharmaceuticals Inc.
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