C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01) A61K 39/12 (2006.01) C07K 14/08 (2006.01) C07K 16/10 (2006.01) C07K 16/42 (2006.01) C12N 5/10 (2006.01) C12N 15/40 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2142902
The invention provides a virus of icosahedral structure having a diameter of about 72nm, double-stranded RNA in seven segments of molecular weights 4.0, 3.9, 2.3, 2.2, 1.6, 1.4 and 1.3 kb, which is capable of infecting human neural crest cells and other human ectodermal cells, causes N-myc amplification in infected cells and is obtainable from human neuroblastoma cells. The invention further provides the RNA of the virus and DNA corresponding thereto as well as fragments thereof and cell lines transfected with the virus. Antigens of use in vaccines may comprise attenuated or inactivated forms of the virus. The invention also extends to antibodies against the virus and diagnostic kits for virus assay comprising such antibodies or the viral antigen.
Applied Research Systems Ars Holding N.v
Kirby Eades Gale Baker
LandOfFree
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