Viruses and virus-like particles for multiple antigen and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01) C07K 14/01 (2006.01) C07K 14/08 (2006.01) C07K 14/16 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2490866

The present invention relates to the display of antigenic or allergenic components along with a tissue-targeting component on viruses or virus-like particles. Capsid protein genes are recombinantly modified to contain the specified components, then expressed within a host organism, such as yeasts, bacteria, or algae, and allowed to spontaneously form active virus particles or virus-like particles. The recombinant complexes (virus or virus-like particle) can then be purified or used in situ as a therapeutic tool for disease or allergy prevention. The expression of multivalent and multifunctional components to increase the immunogenicity of the recombinant complexes, especially on oral administration, is provided.

Selon cette invention, des composants antigéniques ou allergènes sont présentés, de même qu'un composant de ciblage de tissus sur des virus ou des particules pseudovirales. Des gènes de la protéine capside sont modifiés par recombinaison pour qu'ils contiennent les composants spécifiés, après quoi ils s'expriment dans un organisme hôte, tel que des levures, bactéries ou algues, et peuvent former spontanément des particules virales ou des particules pseudovirales actives. Les complexes de recombinaison (virus ou particule pseudovirale) peuvent ensuite être purifiés ou utilisés in situ comme outil thérapeutique de prévention de maladies ou allergies. Cette invention concerne également l'expression de composants multivalents et multifonctionnels pour accroître l'immunogénicité des complexes de recombinaison, en particulier lors d'une administration par voie orale.

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