Viruses targeted to hypoxic cells and tissues

Details Viruses targeted to hypoxic cells and tissues Viruses targeted to hypoxic cells and tissues

A - Human Necessities

61

K

A61K 39/235 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/19 (2006.01) C12N 15/33 (2006.01) C12N 15/34 (2006.01) C12N 15/64 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2423833

The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel compositions of the invention comprise a recombinant virus genetically engineered to have an hypoxia- responsive element, or a multiplicity of such elements, operably linked to a promoter which is operably linked to a gene or genes which regulate or modulate replication of the virus or encode a therapeutic molecule. The invention also includes constructs useful for screening for agents which interact with proteins or genes in the hypoxia-inducible pathway.

L'invention concerne des compositions contenant un virus recombinant qui se réplique sélectivement dans des cellules et des tissus en état d'hypoxie ou dont une voie du facteur inductible par l'hypoxie (HIF) est activée. Ces compositions contiennent un virus recombinant génétiquement modifié afin qu'il comporte un élément sensible à l'hypoxie, ou une multiplicité de tels éléments, liés de manière opératoire à un promoteur, lui-même lié de manière opératoire à un gène ou à des gènes qui régulent ou modulent la réplication du virus ou qui codent pour une molécule thérapeutique. L'invention concerne aussi des constructions utiles pour le criblage d'agents qui interagissent avec des protéines ou avec des gènes dans la voie inductible par l'hypoxie.

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