C - Chemistry – Metallurgy – 08 – H
Patent
C - Chemistry, Metallurgy
08
H
530/15.2
C08H 1/06 (2006.01) A61L 27/24 (2006.01) C07K 14/78 (2006.01) A61F 2/00 (2006.01)
Patent
CA 1284250
File No. 32832 CAN 4A Abstract of the Disclosure Native collagen is reacted with a di or tri-carboxylic acid halide, di or tri-sulfonyl halide, di or tri-anhydride, or di or tri-reactive active ester coupling agent to produce a chemically-modified collagen compound wherein one or more native collagen molecules are coupled at at least one lysine epsilon amino group by a discarbonyl, tricarbonyl, disulfonyl or trisulfonyl coupling group, or a coupling group having a plurality of moieties, at least two of which are carbonyl or sulfonyl groups. The reaction is done in a controlled manner so that the degree of cross-linking is limited. Any remaining lysine epsilon amino groups present in the coupled collagen product may be converted to carboxyamido or sulfonamido groups by acid halide, anhydride, sulfonyl halide or active ester amine-modifying agents. The resultant product when dissolved in a physiological buffer provides a viscoelastic solution having therapeutic application in a variety of surgical procedures, particularly in ophthalmic surgery. This viscoelastic solution "melts," i.e., exhibits a dramatic loss of viscosity, when subjected to temperatures of between 32 and 48°C.
516722
Devore Dale P.
Scherrer Robert A.
Scholz Matthew T.
Minnesota Mining And Manufacturing Company
Smart & Biggar
LandOfFree
Viscoelastic collagen solution for ophthalmic use and method... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Viscoelastic collagen solution for ophthalmic use and method..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Viscoelastic collagen solution for ophthalmic use and method... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1223014