Viscosity modulating substance and use thereof

Details Viscosity modulating substance and use thereof Viscosity modulating substance and use thereof

A - Human Necessities

61

K

A61K 38/05 (2006.01) A61P 7/00 (2006.01) G01N 33/49 (2006.01)

Patent

CA 2385454

It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) lowers whole blood viscosity in patients, including those suffering from sickle cell disease and plasma cell dyscrasias. Upon in vivo APM treatment, patients experienced a significant lowering of whole blood viscosity. In vitro addition of APM to patients samples having elevated whole blood viscosity resulted in reduced viscosity over time. These in vitro and in vivo results identify APM as a therapeutic agent for molecular diseases which lead to elevated whole blood viscosity. A method by which APM treatment can be monitored is also disclosed.

On a découvert que N-L-alpha-aspartyl-L-phénylalanine 1-méthyl ester (APM) abaisse la viscosité sanguine totale chez des patients, y compris ceux qui souffrent de drépanocytose et de dysglobulinémie plasmocytaire. Lors d'un traitement à l'APM in vivo, on a constaté chez des patients une baisse significative de la viscosité sanguine totale. L'ajout in vitro d'APM dans des prélèvements de patients présentant une viscosité sanguine totale élevée a entraîné une réduction de cette viscosité au fil du temps. Ces résultats in vitro et in vivo montrent qu'APM est un agent thérapeutique destiné à des maladies moléculaires qui induisent une élévation de la viscosité sanguine totale. Cette invention concerne aussi une technique permettant de surveiller le traitement à l'APM.

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