Visual function disorder improving agents containing rho...

A - Human Necessities – 61 – K

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A61K 31/437 (2006.01) A61P 27/02 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2443918

Visual function improving agents containing compounds having an Rho kinase inhibitory activity, in particular (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4- (1-aminoethyl)benzamide, as the active ingredient. Because of having effects of promoting axon extension in retinal gangliocytes and promoting regeneration of optic nerve cells, these agents are useful in treating visual function errors in association with various eye diseases caused by damage, defect, degeneration, etc. in retina and optic nerve.

La présente invention concerne des agents servant à améliorer la fonction visuelle. Lesdits agents comportent une activité inhibitrice de la Rho kinase, y compris (R) - (+) -N- (1H-pyrrolo[2,3-b]pyridine-4-yl)-4-(1-aminoéthyl)benzamide, comme ingrédient actif. A cause de leurs effets favorisant l'extension des axones dans les cellules ganglionnaires rétiniennes et la régénération des cellules nerveuses optiques, on utilise ces agents dans le traitement des dysfonctionnements visuels liés à diverses maladies des yeux provoquées par un accident, une défaillance, une dégénération etc. du nerf optique et rétinien,

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