Vitamin d amide derivatives

Details Vitamin d amide derivatives Vitamin d amide derivatives

C - Chemistry, Metallurgy

07

D

C07D 295/185 (2006.01) A61K 31/59 (2006.01) A61K 31/695 (2006.01) C07C 401/00 (2006.01) C07D 207/325 (2006.01) C07D 231/12 (2006.01) C07D 233/02 (2006.01) C07D 277/04 (2006.01) C07D 295/215 (2006.01) C07D 473/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2162272

Novel 1.alpha.-hydroxy vitamin D derivatives and their 20-epi analogues, comprising compounds of general formula (I) where R1 and R2, which may be the same or different, each represents a hydrogen atom or an aliphatic, cycloaliphatic, araliphatic or aryl group or together with the nitrogen atom to which they are attached form a heterocyclic group; R3 represents a methyl group having .alpha.- or .beta.-configuration; X represents a valence bond or a C1-2 alkylene group; Y represents -O-, -S-, CH2- or -NR- where R is a hydrogen atom or an organic group; Z represents a valence bond or a C1-3 alkylene group; and A = represents a cyclohexylidene moiety characteristic of the A-ring of a 1.alpha.-hydroxylated vitamin D or analogue thereof, with the proviso that when -X-Y-Z together represent an alkylene group containing up to 4 carbon atoms A = does not carry an exocyclic methylene group at the 10-position. Active compounds of the invention exhibit cell modulating activity while exhibiting a substantial lack of calcaemic effect.

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