Vitamin d amide derivatives

Details Vitamin d amide derivatives Vitamin d amide derivatives

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61K 31/695 (2006.01) C07D 295/185 (2006.01) C07D 309/12 (2006.01) C07D 405/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2121678

Novel 1.alpha.-hydroxy vitamin D derivatives and their 20-epi analogues, comprising compounds of formula (I) and corresponding 5,6-trans isomers, where Y represents an alkylene or alkenylene group containing up to 4 carbon atoms; R1 and R2 independently represent a hydrogen atom or a lower alkyl or cycloalkyl group or R1R2N- represents a heterocyclic group; and R3 and R4 independently represent a hydrogen atom or an O-protecting group. Active compounds, in which R3 and R4 are hydrogen atoms or metabolically labile O-protecting groups exhibit potent cell modulating effect but minimal effect on calcium metabolism.

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