Vitamin d analogues

Details Vitamin d analogues Vitamin d analogues

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61K 31/66 (2006.01) A61K 31/70 (2006.01) C07F 7/18 (2006.01) C07F 9/117 (2006.01) C07H 15/207 (2006.01)

Patent

CA 2044280

Compounds of Formula I (below) are provided herein. (see formula I) Derivatives of such compound of Formula I in which at least one hydroxy group has been transformed into --O-acyl, or --O-glycosyl or phosphate groups, :such groups being hydrolysable in vivo,are also provided. In such compound of Formula I, R stands for a group of Formula II (see formula II) where n is an integer of from J. to 7; R1 and R2, which may be the same or different, stand for hydrogen, C1-C5-alkyl, C3-C7-cycloalkyl, or, taken together with the carbon atom which is starred in Formula II, bearing the group X, R1 and R2 can form a C3-C8 carbocyclic ring; and X stands for hydrogen or hydroxy. Such compounds find use in both human and veterinary practice for preparing a pharmaceutical composition, and for the use in the treatment and prophylaxis of autoimmune diseases, including diabetes mellitus and hypertension, inflammatory diseases, including rheumatoid arthritis and asthma, and diseases characterized by abnormal cell differentiation, and/or cell proliferation and/or imbalance of the immune system.

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