Vitamin d compounds and method of preparing these compounds

Details Vitamin d compounds and method of preparing these compounds Vitamin d compounds and method of preparing these compounds

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07D 309/12 (2006.01) C07D 317/20 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2140382

The invention relates to a vitamin D compound of the general formula Image wherein: R1 is a hydrogen atom or a hydroxy protecting group; Z is a group of the general formula Image wherein R2 and R3 are each individually straight or branched, substituted or unsubstituted, (C1-C6)alkyl groups, (C2- C6)alkenyl groups, (C3-C6)cycloalkyl groups or phenyl groups; or wherein R1 and R3 together with the interconnecting oxadimethylene biradical form a 5-7 membered ring-closed (C1- C4)alkyl substituted hemiacetal; with the proviso, that R2 and R3 are not both or individually methyl groups; A and B are each individually hydrogen atoms or methyl groups, or A and B form together a methylene group. The invention also relates to a method of preparing these compounds and to their use in pharmacology. The invention further relates to valuable new intermediates.

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