C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 401/00 (2006.01) A61K 31/592 (2006.01) A61K 31/593 (2006.01) A61P 3/02 (2006.01) A61P 17/00 (2006.01) C07C 235/06 (2006.01) C07D 295/185 (2006.01) C07F 7/18 (2006.01) C07J 7/00 (2006.01) C07J 9/00 (2006.01)
Patent
CA 2411409
The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalcemic effect. The present invention provides a vitamin D derivative of Formula (1): (see formula 1) wherein X represents an oxygen atom or a sulfur atom; m represents a number of 1 to 3; R1 and R2 each represent a hydrogen atom or an alkyl group; R4 and R5 each represent a hydrogen atom or a hydroxyl group, etc.; R3 represents -YR8, etc.; R6 represents a hydrogen atom, etc.; and R7 represents a hydrogen atom, etc.
L'invention concerne des dérivés de vitamine D physiologiquement très actifs, convenant pour des médicaments, en particulier pour des traitements contre les dermatoses telles que le psoriasis, dont l'effet d'élévation du taux de calcium est réduit. Ces dérivés sont représentés par la formule générale (I) : (I) dans laquelle X représente l'oxygène ou le soufre, m est un nombre de 1 à 3, R¿1? et R¿2? représentent chacune l'hydrogène ou l'alkyle, R¿4? et R¿5? représentent chacun l'hydrogène, l'hydroxyle ou analogues, R¿3? représente YR¿8? ou un composant analogue, R¿6? représente l'hydrogène ou un composant analogue, et R¿7? représente l'hydrogène ou un composant analogue.
Emura Takashi
Kawase Akira
Morikawa Kazumi
Ohmori Masayuki
Shimizu Kazuki
Chugai Seiyaku Kabushiki Kaisha
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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