C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/42 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C07C 63/04 (2006.01) C07C 69/76 (2006.01) C07C 235/84 (2006.01) C07D 257/04 (2006.01) C07D 257/06 (2006.01)
Patent
CA 2544501
The present invention relates to novel, non-secosteroidal, hydroxyl substituted, carbon- linked diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1.alpha.,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
La présente invention concerne de nouveaux composés de diaryle à liaison carbone, substitués par hydroxyle, non sécostéroïdes, ayant une activité de modulation du récepteur de la vitamine D (VDR), et étant moins hypercalcémiques que la 1.alpha.,25 dihydroxy vitamine D3. Ces composés sont utiles pour traiter les maladies osseuses et le psoriasis.?¿
Bunel Emilio Enrique
Gajewski Robert Peter
Jones Charles David
Lu Jianliang
Ma Tianwei
Bunel Emilio Enrique
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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