Vitamin d response element binding protein

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2245960

The invention relates to the discovery and purification of novel vitamin D response element binding proteins. Vitamin D response element binding proteins are distinct from the vitamin D receptor. Vitamin D response element binding proteins can interfere with the biological activity of the vitamin D receptor and other related intracellular receptor proteins. One aspect of the invention is to provide purified vitamin D response element binding proteins. Another aspect of the invention is to provide antibodies capable of binding to the vitamin D response element binding proteins of the invention. Another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between vitamin D response element binding protein and vitamin D response elements.

L'invention concerne la découverte et la purification de nouvelles protéines de liaison de l'élément de réponse à la vitamine D. Les protéines de liaison de l'élément de réponse à la vitamine D sont distinctes du récepteur de la vitamine D. Les protéines de liaison de l'élément de réponse à la vitamine D peuvent perturber l'activité biologique du récepteur de la vitamine D et d'autres récepteurs protéiques intracellulaires apparentés. Un aspect de l'invention concerne des protéines de liaison de l'élément de réponse à la vitamine D purifiées. Un autre aspect de l'invention a trait à des anticorps capables de se lier à des protéines de liaison de l'élément de réponse à la vitamine D de l'invention. Un autre aspect de l'invention concerne des dosages de détection ou de criblage de composés thérapeutiques perturbant l'interaction entre une protéine de liaison d'éléments de réponse à la vitamine D et des éléments de réponse à la vitamine D.

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