Vitamin d.sub.3 derivatives and process for producing the same

C - Chemistry – Metallurgy – 07 – D

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204/91.05, 260/3

C07D 319/02 (2006.01)

Patent

CA 1191858

Abstract of the Disclosure: There are disclosed 6,19-epidioxyvitamin D3 deriva- tives which are represented by the formula Image wherein Rl, R2 and R3 are each a hydrogen atom or a hydroxyl group; when Rl is a hydrogen atom, R2 represents a hydroxyl group and R3 is a hydrogen atom or a hydroxyl group; when both Rl and R2 represent a hydroxyl group, R3 is a hydrogen atom or a hydroxyl group; and when Rl is a hydroxyl group and R2 is a hydroqen atom, R3 represents a hydroxyl group. The compounds are highly capable of inducing differentiation of human myeloid leukemia cells with minimum effects on calcium metabolism and are useful as an agent to treat leukemia.

416816

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