Vitamin d3 analogs

Details Vitamin d3 analogs Vitamin d3 analogs

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/593 (2006.01)

Patent

CA 2135708

Compounds of the formula (see formula I) wherein R is hydrogen, hydroxy, or fluorine, X is H2 or ~CH2, and the 23,24-double bond is E or Z, are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of tumors such as breast cancer, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne and seborrheic dermatitis. They are prepared by removing the silyl protecting groups from corresponding compounds with silyl protected hydoxy groups.

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