Vitamin d3 analogs

C - Chemistry – Metallurgy – 07 – C

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C07C 401/00 (2006.01) A61K 31/59 (2006.01)

Patent

CA 2205275

Compounds of the formula (see Formula I) wherein R is hydrogen, fluorine, or hydroxy, R2 is hydrogen, lower alkyl or halogen, X is =CH2 or when R is hydroxy, X is (H,H) or =CH2, and A is -C .ident. C- , (see Formula II), (see Formula III) or -CH2-CH2-, are useful in the treatment of hyperproliferative skin disorders, neoplastic diseases, sebaceous gland diseases, and conditions associated with photodamaged skin.

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