Vitamin d3 analogs

Details Vitamin d3 analogs Vitamin d3 analogs

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/593 (2006.01)

Patent

CA 2378803

Compounds of formula (I) wherein R1 is hydrogen or an alkyl group; R2 is hydrogen or an alkyl group; or R1, R2 and C20 together are cyclopropyl; A is a, b, c or d; R3 is alkyl, hydroxy- alkyl or fluoroalkyl; and R4 is alkyl, hydroxy-alkyl or fluoroalkyl which are useful in the treatment of breast cancer, prostate cancer, myeloid leukemia benign prostate growth, baldness and osteoporosis.

L'invention concerne des composés représentés par la formule (I) dans laquelle R1 représente un hydrogène ou un groupe alkyle ; R2 représente un hydrogène ou un groupe alkyle ; ou R1, R2 et C20 pris ensemble représentent un cyclopropyle ; A représente a, b, c ou d; R3 représente un alkyle, un hydroxy-alkyle ou un fluoroalkyle ; et R4 représente un alkyle, un hydroxy-alkyle ou un fluoroalkyle. Ces composés s'utilisent dans le traitement du cancer du sein, du cancer de la prostate, de l'hypertrophie bénigne de la prostate, de la leucémie myéloïde, de la calvitie et de l'ostéoporose.

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