C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) A61K 31/59 (2006.01) C07C 401/00 (2006.01)
Patent
CA 2133144
The invention relates to the compounds 1,25-dihydroxy-16-ene-24-oxo- cholecalciferol and 1,24,25-trihydroxy-16-ene-cholecalciferol which stimulate differentiation of HL-60 cells, rendering them useful as an agent for the treatment of neoplastic diseases such as leukemia, and also decrease proliferation of human keratinocytes, rendering them useful as an agent for the treatment of hyperproliferative disorders of the skin such as psoriasis. They are prepared by perfusing 1,25-dihydroxy-16-ene-cholecalciferol in rate kidneys, extracting the perfusate and isolating 1,25-dihydroxy-16-ene- 24-oxo-cholecalciferol and 1,24,25-trihydroxy-16-ene-cholecalciferol.
Mclane John Arthur
Reddy Satyanarayana G.
Uskokovic Milan Radoje
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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