Vitamin d3 analogues and pathway to mediate disorders

Details Vitamin d3 analogues and pathway to mediate disorders Vitamin d3 analogues and pathway to mediate disorders

A - Human Necessities

61

K

A61K 31/59 (2006.01) A61K 31/575 (2006.01)

Patent

CA 2179288

Methods for controlling genomic and nongenomic cellular responses which are mediated by 1.alpha.,25-(OH)2 vitamin D3[1.alpha.,25-(OH)2D3]. The method involves treating cells which exhibit nongenomic responses to 1.alpha.,25- (OH)2D3 with the vitamin C3 analogues 1,25(OH)2-previtamin D3 or 1.beta.,25- (OH)2 vitamin D3 [1.beta.,25-(OH)2D3]. The 1,25(OH)2-previtamin D3 functions as an agonist to promote the cellular response while the 1.beta.,25-(OH)2D3 functions as an antagonist. Transcaltachia is one of the nongenomic responses which is affected and can be controlled by administration of 1,25(OH)2- previtamin D3 or 1.beta.,25-(OH)2D3. Fifteen additional analogues are disclosed which may be used to control genomic and/or nongenomic cellular responses.

Procédés de régulation de réponses cellulaires génomiques et non génomiques induites par 1.alpha.,25-(OH)¿2? vitamine D¿3?[1.alpha.,25-(OH)¿2?D¿3?]. Le procédé consiste à traiter des cellules présentant des réponses non génomiques à 1.alpha.,25-(OH)¿2?D¿3? à l'aide des analogues de vitamine D¿3? 1,25(OH)¿2?-provitamine D¿3? ou 1.beta.,25-(OH)¿2? vitamine D¿3? [1.beta.,25-OH)¿2?D¿3?]. La 1,25(OH)¿2?-provitamine D¿3? fait office d'agoniste stimulant la réponse cellulaire tandis que la 1.beta.,25-(OH)¿2?D¿3? fait office d'antagoniste. La transcaltachia est une des réponses non génomique affectée et pouvant être régulée par administration de 1,25(OH)¿2?-provitamine D¿3? ou 1.beta.,25-(OH)¿2?D¿3?. L'invention concerne également quinze autres analogues que l'on peut utiliser pour réguler des réponses cellulaires génomiques et/ou non génomiques.

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