A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C12N 5/077 (2010.01) C12N 15/113 (2010.01) A61K 31/085 (2006.01) A61K 31/7088 (2006.01) A61K 35/34 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2482996
This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject an amount of an agent effective to cause cardiomyocyte proliferation within the subject's heart so as to thereby treat the disorder. This invention further provides the instant method wherein the agent is human endothelial progenitor cells, G-CSF, GM-CSF, SDF-1, and IL-8. This invention also provides methods of determining the susceptibility of a cardiomyocyte in a subject to apoptosis.
L'invention concerne une méthode permettant de traiter un trouble cardiaque chez un sujet impliquant une perte de cardiomyocytes. Ladite méthode consiste à administrer à un sujet une quantité d'un agent efficace pour provoquer la prolifération des cardiomyocytes dans le coeur dudit sujet afin de traiter ainsi un trouble. L'invention concerne également une méthode dans laquelle l'agent est constitué de cellules progénitrices endothéliales humaines G-CSF, GM-CSF, SDF-1 et IL-8. L'invention concerne enfin des méthodes permettant de déterminer la susceptibilité d'un cardiomyocyte chez un sujet à une apoptose.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Trustees Of Columbia University In The City Of New York
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