Vitamin d_ derivatives having a substituent at 2-position

C - Chemistry – Metallurgy – 07 – C

Patent

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204/91.05, 260/6

C07C 401/00 (2006.01) C07J 9/00 (2006.01) C07J 41/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1330806

ABSTRACT 1.alpha.-hydroxy vitamin D3 derivatives of the formula: Image where R1 is a hydroxyl group, an amino group or the group OR' (where R' is a lower alkyl group having 1 to 7 carbon atoms that may or may not be substituted by a hydroxyl group, a halogen atom, a cyano group, a lower alkoxy group having 1 to 3 carbon atoms, an amino group, or an acylamino group); R2 is a hydrogen atom or a hydroxyl group, and a process for preparing the same are disclosed. The compounds represented by the formula above have a calcium control action and the ability to induce differentiation in tumor cells and, therefore, are useful as an antitumor agents and a medicine for treating calcium dysbolism-caused diseases.

496985

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