Vitamin e and derivatives prevent damage in red cells...

Details Vitamin e and derivatives prevent damage in red cells... Vitamin e and derivatives prevent damage in red cells...

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61K 31/355 (2006.01) A61K 35/14 (2006.01) A61K 35/18 (2006.01) A61L 2/00 (2006.01) C12N 7/04 (2006.01) C12N 13/00 (2006.01)

Patent

CA 2180977

Disclosed is an improved process for irradiating cell-containing compositions, especially, red cell-containing compositions, wherein vitamin E or a derivative thereof is added to the cell-containing composition prior to, during or after such irradiation. Addition of vitamin E or a derivative thereof is protective of cells in such compositions, but not of virus. Cells irradiated using the inventive process show a reduced leakage of K+ from cells and also a reduced loss of negative charges from the cell membrane compared to cells subjected to the similar process wherein vitamin E or a derivative thereof are not used. In addition, red blood cells sterilized by this process are better preserved during storage and their life-time in the circulation in vivo is greatly enhanced.

L'invention concerne un procédé amélioré d'exposition à des rayons de composition contenant des globules, en particulier des globules rouges, procédé selon lequel on ajoute de la vitamine E ou un dérivé de celle-ci à la composition contenant les globules, avant ou après exposition aux rayons. L'addition de vitamine E ou d'un de ses dérivés protège les globules contenus dans de telles compositions, mais non les virus. Les globules exposés au rayonnement conformément au procédé selon l'invention présentent une fuite réduite de K?+¿ et également une perte réduite de charges négatives à partir de leur membrane, si l'on compare avec des globules soumis à un procédé similaire n'impliquant pas l'utilisation de la vitamine E ou d'un de ses dérivés. En outre, les globules rouges stérilisés selon ce procédé ont une meilleure aptitude au stockage et leur durée de vie in vivo est nettement augmentée.

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