Vitronectin receptor antagonist pharmaceuticals for use in...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/415 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07F 9/6503 (2006.01) C07F 9/6524 (2006.01) C07F 9/6558 (2006.01) C07F 13/00 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 9/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2413957

The present invention describes novel kits and compositions comprising compounds of the formula (I):(Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer in combination therapy in a patient. The present invention provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety.

L'invention concerne de nouveaux ensembles et des compositions comprenant des composants de formule (I):(Q)¿d?-L¿n?-C¿h?, (I) servant à diagnostiquer et à traiter le cancer en polythérapie chez un patient. L'invention concerne également de nouveaux composants utilisés afin de traiter l'arthrite rhumatoïde. Les produits pharmaceutiques sont composés d'un groupe fonctionnel de ciblage qui se lie à un récepteur qui est régulé en amont pendant l'angiogénese, un groupe de liaison facultatif et un radio-isotope thérapeutiquement efficace ou un groupe fonctionnel imageable diagnostiquement efficace.

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