Vitronectin receptor antagonists

Details Vitronectin receptor antagonists Vitronectin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 239/02 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) C07D 211/80 (2006.01) C07D 213/73 (2006.01) C07D 213/74 (2006.01) C07D 217/12 (2006.01) C07D 217/22 (2006.01) C07D 239/14 (2006.01) C07D 277/18 (2006.01) C07D 277/42 (2006.01) C07D 405/12 (2006.01) C07D 411/00 (2006.01)

Patent

CA 2303487

Compounds of formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis wherein: A is CH2 or O; R1 is H, halo or C1-6alkyl; R2 is H, C1-6alkyl or CH2NR''R''; X is O or CH2; Y is (a), (b), (c), (d), (e), (f) or (g); G is NR'', S or O; R' is H, C1- 6alkyl, OC1-6alkyl, SC1-6alkyl, NR''R'' or halo; each R'' independently is H or C1-6alkyl; and s is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.

L'invention a trait à des composés représentés par la formule (I) qui constituent des antagonistes du récepteur de la vitronectine et sont utiles dans le traitement de l'ostéoporose, ou à un sel pharmaceutiquement acceptable de ces composés. Dans la formule, A est CH¿2? ou O; R?1¿ est H, halo ou alkyle en C¿1-6?; R?2¿ est H, alkyle en C¿1-6? ou CH¿2?NR"R"; X est O ou CH¿2?; Y est (a), (b), (c), (d), (e), (f) ou (g); G est NR", S ou O; R' est H, alkyle en C¿1-6?, OC¿1-6?alkyle, SC¿1-6?alkyle, NR"R" ou halo; chaque R" est indépendamment H ou alkyle en C¿1-6?, et s est 0, 1 ou 2.

Affiliated with

Also associated with

Rating

Vitronectin receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vitronectin receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vitronectin receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1570250