Vla-4 antagonists

Details Vla-4 antagonists Vla-4 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/44 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2558893

Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn~s disease, multiple sclerosis, asthma, and rheumatoid arthritis.

L'invention concerne des composés représentés par la formule I, qui sont des antagonistes de VLA-4 utiles pour inhiber ou prévenir l'adhérence cellulaire et les pathologies induites par celle-ci. Ces composés sont formulés en compositions pharmaceutiques destinées à traiter des affections intestinales inflammatoires, y compris la rectocolite hémorragique et la maladie de Crohn, la sclérose en plaques, l'asthme et la polyarthrite rhumatoïde.

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