Vla-4 antagonists

Details Vla-4 antagonists Vla-4 antagonists

C - Chemistry, Metallurgy

07

C

C07C 275/42 (2006.01) A61K 31/16 (2006.01) A61K 31/167 (2006.01) A61K 31/17 (2006.01) C07C 237/22 (2006.01)

Patent

CA 2318639

Compounds of formula (I) and their pharmaceutically acceptable salts are VLA-4 antagonists. They are useful in inhibiting cell adhesion and in the therapeutic or prophylactic treatment of inflammatory and autoimmune diseases, particularly inflammatory airways diseases. They are particularly useful in reducing post-surgical inflammation, especially that resulting from transplant surgery.

Les composés correspondant à la formule (I) ainsi que leurs sels acceptables du point de vue pharmaceutique sont des antagonistes du VLA-4. Ils inhibent efficacement l'adhésion cellulaires et se révèlent comme des plus utiles en matière de traitement ou de prophylaxie de maladies inflammatoires ou auto-immunes, notamment des maladies inflammatoires des voies respiratoires. Ils s'avèrent particulièrement efficaces s'agissant d'atténuer une inflammation post-chirurgicale, résultant notamment d'une greffe.

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