Voltage-gated ion channel mutants for use in identifying ion...

Details Voltage-gated ion channel mutants for use in identifying ion... Voltage-gated ion channel mutants for use in identifying ion...

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) C07K 14/705 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2596983

The present invention provides novel methods and compositions for identifying ion channel modulating compounds, including atrial-selective antiarrhythmic agents and ion channel modulating compounds that preferentially modulate K+ channels. The ion channel modulating compounds identified according to these methods are associated with a reduced incidence of ventricular proarrhythmia.

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