Volume maintaining osteoinductive/oesteoconductive compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/32 (2006.01) A61F 2/28 (2006.01) A61K 33/00 (2006.01) A61L 27/02 (2006.01) A61L 27/36 (2006.01) A61L 27/38 (2006.01) A61L 31/00 (2006.01) A61P 19/08 (2006.01) A61F 2/00 (2006.01) A61F 2/46 (2006.01)

Patent

CA 2425556

An osteoinductive/osteoconductive composition prepared from a quantity of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.

L'invention concerne une composition de type ostéoinducteur/ostéoconducteur établie à partir d'une certaine quantité d'éléments d'os fibreux déminéralisés qui possèdent un rapport moyen surface/volume compris entre environ 100:1 et environ 20:1, d'une certaine quantité d'éléments d'os non fibreux de forme essentiellement régulière qui possèdent un rapport moyen surface/volume inférieur ou égal à environ 10:1 et d'une quantité suffisante de vecteur liquide biocompatible pour présenter la composition sous la forme d'une masse déformable. L'invention concerne également un procédé relatif à l'utilisation de la composition pour la réparation d'un site de défectuosité osseuse.

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