Wa545 compositions

Details Wa545 compositions Wa545 compositions

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/46 (2006.01) C07K 14/51 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2295086

Purified WA545 proteins and processes for producing them are disclosed. DNA molecules encoding the WA545 proteins are also disclosed. The proteins, members of the TGF-.beta. superfamily of growth factors, may be used to induce, enhance and/or inhibit the information, growth, proliferation, differentiation, maintenance of mesodermal tissue, including neural and muscle tissue. The proteins may also be useful for treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.

La présente invention concerne des protéines WA545 purifiées et les procédés de production de ces protéines. L'invention concerne également des molécules d'ADN codant les protéines WA545. Ces protéines, qui appartiennent à la superfamille TGF-.beta. des facteurs de croissance, conviennent à l'induction, au renforcement et/ou à l'inhibition de l'information, de la croissance, de la prolifération, de la différentiation, et du maintien du tissu mésodermique, y compris des tissus neuraux et musculaires. Ces protéines conviennent également, d'une part au traitement des défauts tissulaires affectant les os, les cartilages ou les tissus conjonctifs, et d'autre part à la guérison des blessures et les réparations tissulaires concernées.

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