Water dispersible film

Details Water dispersible film Water dispersible film

A - Human Necessities

61

F

A61F 13/00 (2006.01)

Patent

CA 2538362

A soft, pliable cellulose acetate phthalate (CAP) - hydroxypropyl cellulose (HPC) composite film is provided which is generated by casting from organic solvent mixtures containing ethanol. The film rapidly reduces the infectivity of several sexually transmitted disease pathogens, including the human immunodeficiency virus (HIV-1), herpesvirus (HSV), non-viral sexually transmitted disease pathogens (such as Neisseria gonorrhoeae, Haemophilus ducreyi, Chlamydia trachomatis and Treponema pallidum) and bacteria associated with bacterial vaginosis (BV). The film is converted into a gel/cream and thus does not have to be removed following application and use. In addition to being a topical microbicide, the film can be employed for the mucosal delivery of pharmaceuticals other than cellulose acetate phthalate.

L'invention concerne un film composite phtalate acétate de cellulose (CAP) hydroxypropylcellulose (HPC) mou et pliable, qui est produit par coulage à partir de mélanges de solvants organiques contenant de l'éthanol. Le film réduit rapidement l'infectivité de plusieurs agents pathogènes de maladies sexuellement transmissibles, y compris le virus de l'immunodéficience humaine (VIH-1), le virus de l'herpès (HSV), des agents non-viraux pathogènes de maladies sexuellement transmissibles (tels que Neisseria gonorrhoeae, haemophilus ducreyi, Chlamydia trachomatis et Treponema pallidum) ainsi que des bactéries associées à la vaginose bactérienne (BV). Le film est transformé en gel/crème et n'a donc pas besoin d'être enlevé après application et utilisation. Outre le fait d'être un microbicide topique, le film peut être utilisé pour administrer aux muqueuses des produits pharmaceutiques autres que le phtalate acétate de cellulose.

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